Endocrine Abstracts

Current strategies for identifying substances that adversely affect the thyroid hormone (TH) system (e.g. endocrine disrupting compounds [EDC]) are exclusively focussed on changes in serum TH concentrations and thyroid histopathology. This is based on the assumption that altered TH concentrations in serum directly result in impaired TH action in tissues. However, TH action is also regulated by hormone transport into cells and tissues (e.g. MCT8), activation of T4 to T3 by deio...